A Secret Weapon For ceesdekker.net
A Secret Weapon For ceesdekker.net
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Dynamics of initiation, termination and reinitiation of DNA translocation by the motor protein EcoR124I
Our do the job was quickly followed up by others, most notably by Phaedon Avouris and colleagues at IBM, who in October 1998 published their findings on transistors produced from single- and multi-walled carbon nanotubes in Applied Physics Letters.
This yielded a breakthrough. Within just a few months, we were in the position to measure transportation through someone single-walled carbon nanotube. Determined by reduced-temperature experiments by an excellent PhD student in my team, Sander Tans (now a valued colleague and professor at Delft College of Engineering having an Energetic investigate lab at AMOLF in Amsterdam), we showed that carbon nanotubes ended up genuine quantum wires with quite long (micrometres) electronic coherence lengths — confirming theoretical predictions of metallic conduct.
Experimental section diagram of negatively supercoiled DNA measured by magnetic tweezers and fluorescence,
‘At the beginning we looked at biological devices which has a physical check out and acted on The premise of your resources we understood. It took a several years before we began Doing work extra on the massive biological problems. I then began to connect with it nanobiology, a term that did not exist at the time.
Nanopores symbolize an elegant and flexible Instrument to measure single molecules. We research novel detection modes with solid-point out nanopores and many tips on how to evaluate proteins with nanopores. Initiatives encompass the next:
What if, in lieu of employing standard major-down silicon electronics, transistors could possibly be built from the bottom up using solitary natural and https://www.ceesdekker.net organic molecules because the switching features? This idea, which turned the basis of now’s area of molecular electronics, first emerged inside the nineteen seventies.
There was one particular challenge nevertheless — we did not observe any measurable electrical conduction from the single polymer molecules. We concluded that at The one-molecule amount, conducting polymers were actually not this kind of fantastic conductors, which was fairly disappointing. We Hence broadened our check out to try to locate a lot more promising molecules.
Considering the fact that 2000 he moved to solitary-molecule biophysics and nanobiology, with study from experiments of DNA loop extrusion and supercoiling to DNA translocation by way of nanopores. Much more a short while ago his analysis has centered on learning chromatin composition and cell division with microbes on chip, although he is also aiming to finally Create artificial cells from the bottom up.
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Visualization of unstained DNA nanostructures with Sophisticated in-concentration transmission electron microscopy tactics
The biophysicist from Delft – who has been One of the more cited experts while in the Netherlands For a long time – requires his responsibility to add on the explanation and popularisation of his work for the border of physics and biology really critically and regularly seems inside the media; if not to look at his operate, then about the relationship concerning science and his Christian faith.